A low-dose trial of Viagra (sildenafil) in the treatment of erectile dysfunction in Mexico, dubbed the “Mexican Viagra Trial,” has confirmed the drug has a similar safety profile. But the study’s authors caution that such a drug would potentially lead to serious side effects, especially as it requires a long-term follow-up.
The trial’s results are based on the results of an earlier study of sildenafil citrate, a drug used for treating pulmonary arterial hypertension in men, and on the results of the first three-year follow-up studies of Viagra in men.
“This is the first study to show a strong safety advantage of using sildenafil for the treatment of erectile dysfunction in men,” said senior author Dr. David M. Schondelmeyer, a clinical professor at the Northwestern University Feinberg School of Medicine, Northwestern Feinberg Medical Center, Northwestern Memorial Hospital, and an associate professor of urology at Northwestern Memorial Hospital in Chicago. “It is important to note that the results from the earlier studies may not be as conclusive as we previously thought, but they still may provide some useful information for men who might be taking sildenafil for pulmonary hypertension.”
The study’s authors were not involved in the work. However, they do not accept responsibility for the results and have not taken the drug.
The study was published in the August/September issue of theJournal of Sexual Medicine.
In the past, sildenafil was used to treat pulmonary arterial hypertension in men. However, the drug was first developed by Pfizer and became popular for treating erectile dysfunction in men in the late 1990s. The drug was approved by the FDA in 1999 and has been used off and on for several years.
However, in the past, it was not approved to treat pulmonary arterial hypertension in men. In fact, Pfizer marketed sildenafil for pulmonary arterial hypertension and was not approved to treat erectile dysfunction in men in the early 2000s.
“The safety of sildenafil has not been established in Mexico, so it is important that we do this study with caution,” Schondelmeyer said.
“If we were to try sildenafil for erectile dysfunction, we would expect to see a slight increase in side effects, which are similar to those seen with other medications,” he added.
The researchers also noted that the study did not draw a comparison between Viagra and sildenafil, a drug used for treating pulmonary arterial hypertension.
“If it is a drug that is taken by men, the benefit of it in this population is less than the benefit in the general population,” Schondelmeyer said. “If we were to try sildenafil for the treatment of pulmonary arterial hypertension, we would expect to see a slight increase in side effects.”
Viagra is available only by prescription. If the drug is not prescribed by a doctor, it is usually taken by mouth.
Researchers are still studying the safety of sildenafil for pulmonary arterial hypertension.
The study’s authors also note that other erectile dysfunction medications like Viagra have also been studied for safety.
“In a few clinical studies involving men with erectile dysfunction, the safety of sildenafil was studied,” Schondelmeyer said. “In these studies, patients were given sildenafil at doses of 100 to 200 milligrams twice a day for four to six weeks.”
Viagra is currently in a clinical trial in more than 100,000 men. The results of the trial are expected in the second half of this year. The drug is not yet approved for use in the United States.
The study was funded by Pfizer, the maker of Viagra. Pfizer, the manufacturer of sildenafil, had no role in the study, and no financial relationships were disclosed.
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Originally Published: October 31, 2018 at 12:28 AM EDT
The San Diego Times is a daily news service, which combines the expertise of a syndicated and syndicated by The San Diego Times.Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.
Common side effects reported from Viagra use include:
More severe side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.
As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.
Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.
In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.
asthma is a separate issueAs with most medications, Viagra can cause a slight increase in blood pressure when taken with nitrates.uggishness is not affected by Viagra; sexual stimulation is still required
documented
medicine
asthma medicationmedicines for arthritis
medicines for high blood pressureasthma can occur without warning; many individuals are unaware that they have this side effect.
This is not a complete list of drugs that can cause potentially serious adverse reactions. Immediate medical attention is necessary if you experience any of the following side effects, including:
may also appear after taking nitrates for high blood pressure or treating heart disease. These could be signs of a serious adverse reaction to this medication.
In rare cases, multiple, serious adverse reactions can occur. For example, if these reactions occur several weeks after starting Viagra, they could be the result of a severe allergic reaction.
If you experience any unusual results from taking Viagra, please consult your doctor. You should not take more than one dose of Viagra within a 24-hour period. Additionally, Viagra can cause a slight increase in blood pressure when taken with nitrates.
Stomach ulcers or are present in the stomach, coma, or death associated with Viagra use are uncommon.
Viagra Connect is a new erectile dysfunction treatment which does not require a prescription.
The first of its kind, Viagra Connect is a safe and discreet over-the-counter medication that can legally be bought online without a trip to your doctor.
We need to ensure that this medicine is suitable for the person it is intended for. Therefore, it should only be purchased by the person taking it.
A pharmacist may need to contact you by phone before providing the product. If they cannot reach you within 72 hours, your order may be delayed, or this item may be cancelled from your order.
Please ensure your contact details are correct before ordering this medicine.Suitable forViagra Connect is for men 18 years and older who have difficulty getting and/or keeping an erection hard enough for sex
Age RestrictionYou must be at least 18 years old to purchase this product.
Directions for use:Please read the enclosed leaflet carefully before use.
• take 1 tablet approximately one hour before sexual activity• swallow tablet whole with water• do not take more than 1 tablet a dayViagra Connect starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity.
Hazards and Cautions
Do NOT take if you:
Talk to your pharmacist or doctor before taking if you:
As with all medicines, please ensure you read the patient information leaflet before taking this item.
Please read the enclosed leaflet before using this item.
As with all medicines, please ensure you read the enclosed patient information information leaflet before using this item.
Viagra Connect is available in Ireland for erectile dysfunction treatment which does not require a prescription. The first of its kind, Viagra Connect is a safe and discreet over-the-counter medication that can legally be bought online or over the counter in your pharmacy, without a trip to your doctor.
We need to ensure that this medicine is suitable for the person it is intended for. Therefore, it should only be purchased by the person taking it.
You can select your convenient store to collect your product and fill in the online form required.APharmacist will contact you to let you know your product is ready for collection, or you can buy onlineand complete the questions included.
When purchased online, a pharmacist will contact you by phone if they have any further questions and to advise you on the safe use of this medicine. If they are unable to speak to you when required your order may be delayed or the pharmacy medicine part of your order cancelled.
Please ensure your contact details are correct before ordering this medicine.Suitable for
Viagra Connect is for men 18 years and older who have difficulty getting and/or keeping an erection hard enough for sex
Age RestrictionYou must be at least 18 years old to purchase this product.
Directions for use:
Please read the enclosed leaflet carefully before use.
• take 1 tablet approximately one hour before sexual activity• swallow tablet whole with water• do not take more than 1 tablet a dayViagra Connect starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity.
Hazards and Cautions
Do NOT take if you:
Talk to your pharmacist or doctor before taking if you:
Food Warnings
Do not take if you:
Do not have
high blood pressure
Have or have with the signs and symptoms of an allergic reaction such as feeling warmth, mild to moderate pain, loss of frequency, or a rash.
Have any medical conditions such as heart or blood vessel problems
Have the function of a blood vessel in your penis other than where said blood vessel is located
Have or have with the signs and symptoms of an over the counter drug use
Have or have with the following medical advice:
If you are getting any of the following symptoms, contact your doctor:
If you experience any of the following, then stop use and see your doctor immediately.
Stade de France Pharmacy